- Chronogram: an R package for data curation and analysis of infection and vaccination cohort studiesDavid Greenwood, Marianne Shawe-Taylor, Hermaleigh Townsley, Joshua Gahir, Nikita Sahadeo, Yakubu Alhassan, Charlotte Chaloner, Oliver Galgut, Gavin Kelly, David L V Bauer, Emma C Wall, Mary Y Wu, Edward J Carr Bioinformatics Advances, Volume 4, Issue 1, 2024, vbae146, https://doi.org/10.1093/bioadv/vbae146 Abstract Motivation: Observational cohort studies that track vaccine and infection responses offer real-world data to inform pandemic policy. Translating biological hypotheses, such as whether different patterns of… Read more: Chronogram: an R package for data curation and analysis of infection and vaccination cohort studies
- Targeted gene panel sequencing of liquid and tissue biopsies reveals actionable genomic alterations in Ghanaian metastatic breast cancer casesEmmanuella Amoako abc, Setor Amuzu a, Emmanuel Owusu Ofori b, Harry Sefoga Akligoh a, Randy Tackie a, Barikisu Anna Ibrahim a, Emmanuel Kofi Quaye a, Patrick Kafui Akakpo bcd, Luke Adagrah Aniakwo b, Bashiro Jimah bc, Kofi Ulzen-Appiah bc, David Hutchful a, Aida Manu a, Joyce M Ngoi a, Lily Paemka a, Yakubu Alhassan ae, Ernest Amo Obeng d, Nicole Lim f, Lisa Rajah f, Michelle Pek f…Yaw Bediako a Transl Oncol; 49: 102100, 2024 Nov, https://doi.org/10.1016/j.tranon.2024.102100 Abstract Purpose: Breast cancer is a major cause of cancer-related mortality among African women. The adoption of molecular genomic technologies in the management of cancer cases is limited in Africa. To provide much-needed insights on the feasibility and utility… Read more: Targeted gene panel sequencing of liquid and tissue biopsies reveals actionable genomic alterations in Ghanaian metastatic breast cancer cases
- Cellular immune response to SARS-CoV-2 and clinical presentation in individuals exposed to endemic malariaWe are pleased to share a paper from our first research collaboration with West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) – University of Ghana, where we explored the link between malaria and lower COVID-19 deaths in Africa. This project is supported by Google, Bill & Melinda Gates Foundation and The Rockefeller Foundation.
- Clinical disease activity in autoimmune rheumatic patients receiving COVID-19 vaccinesOur research on the COURAGE cohort of our Heritage Study has been published in BMC Rheumatology! The COvid-19 vaccine immUne Response in Autoimmune rheumatic patients: a Ghanaian Experience (COURAGE) study, led by Dr. Ida Dzifa Dey, followed 38 patients with Systemic lupus erythematous (SLE) and Rheumatoid arthritis (RA) over 12 months at Korle-Bu Teaching Hospital, to access changes in clinical disease activity following COVID-19 vaccination, and to understand vaccine immune response in this subset.
- Radiologic patterns of distant organ metastasis in advanced breast cancer patientsBreast cancer (BC) metastases to the abdomen and pelvis affect the liver, mesentery, retroperitoneum, peritoneum, bladder, kidney, ovary, and uterus. The study documented the radiological pattern and features of the chest, bone, abdominal and pelvic (AP) metastases among advanced breast cancer patients.